Inhibitory effect of boschniakia rossica on den-induced precancerous hepatic foci and its antioxidative activities in rats

摘要

Objective: To investigate the inhibitory effect of Boschniakin rossica (BR) on rat precancerous hepatic foci Induced by diethylnitrosamine (DEN) and its antioxidative Activities. Methods: The expresiso of tumor marker- Placental form glutathione S-transferase (GST-P), p53 and P21 protein were investigated by immunohistochemistry Techniques using ABC method. TNF-α was measured by ELISA and antioxidative activities of SOD, MDA, GSH-Px, GST and CAT were investigated by colorimetric method in Rat serum and mitochondria of liver cells.