Prevention of metastasis to liver by using 5-FU in-traperitoneal chemotherapy in nude mice inoculated with human colonic cancer cells

摘要

AIMS Using a new approach of regional adjuvant chemotherapy to prevent cancer cells hepatic metastasis after radical surgery of large bowel cancer. METHODS A model of liver with metastasis of human colonic cancer (HCC) cells in nude mice was used to observe the effect in prevention of metastasis of HCC cells inoculated via spleen applied with early postoperative intraperitoneal (IP) chemotherapy using large dose of 5-FU. RESULTS The incidence of metastasis to liver was decreased by 40%, the mean number of metastatic liver nodules in each animal was reduced by 50.89% and the mean survival times of each animal was prolonged by 48.21% by using 5-FU 40 mg/NS 40 ml/kg IP for two consecutive days as compared with the controls. CONCLUSIONS IP is a new and more effective regional adjuvant chemotheraputic approach in the prevention of liver metastasis HCC cells after radical surgery of large bowel cancer.