Bioorganometallic Technetium and Rhenium Chemistry: Fundamentals for Applications

摘要

Due to its long half-life of 2.111×10~5 y, technetium, i.e. ~(99)Tc, offers the excellent opportunity of combining fundamental and 'classical' organometallic or coordination chemistry with all methodologies of radiochemistry. Technetium chemistry is inspired by the applications of its short-lived metastable isomer ~(99m)Tc in molecular imaging and radiopharmacy. We present in this article examples about these contexts and the impact of purely basic oriented research on practical applications. This review shows how the chemistry of this element in the middle of the periodic system inspires the chemistry of neighboring elements such as rhenium. Reasons are given for the frequent observation that the chemistries of ~(99)Tc and ~(99m)Tc are often not identical, i.e. compounds accessible for ~(99m)Tc, under certain conditions, are not accessible for ~(99)Tc. The article emphasizes the importance of macroscopic technetium chemistry not only for research but also for advanced education in the general fields of radiochemistry.