Modulation of DNA-Modified Gold-Nanoparticle Stability in Salt with Concatemeric Single-Stranded DNAs for Colorimetric Bioassay Development

摘要

Golden island: Periodically assembled gold nanoparticles (AuNPs) on a long single-stranded DNA (ssDNA) with a repetitive sequence, produced by rolling circle amplification (RCA), form island-like, globular structures under salted conditions (see figure; green = short DNA probe, orange=AuNP, black=long ssDNA from RCA). The AuNPs in such islands retain their original red color whereas unassembled AuNPs form purple aggregates under the same conditions.