Aptamer-based fluorescence sensor for rapid detection of potassium ions in urine

摘要

We unveil a new homogeneous assay-using OliGreen and an ATP-binding aptamer-for the highly selective and sensitive detection of potassium ions. Potassium ions (K~+) are involved in many biological functions, including nerve transmission, regulation of blood pressure and pH, enzyme activation, and the formation of collagen or elastin. Abnormal levels of K~+ ions in biological fluids can cause muscle cramps or weakness, nausea, diarrhoea, frequent urination, dehydration, paralysis, and changes in heart rhythms.