US scientists are targeting an enzyme essential to bacterial metabolism in the search for new antibiotics. Michael Burkart of the University of California, San Diego, and Anton Simeonov from the National Institutes of Health, Bethesda, and coworkersrnhave developed arnhigh-throughput kinetic assay to screen small molecules as inhibitors of surfactin-type phosphopantetheinyl transferase (Sfp-PPTase) enzymes.
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