Characterization And Application Of The Fe(N) And A-Ketoglutarate Dependent Hydroxylase Frbj

Matthew A. DeSieno; Wilfred A. van der Donk; Huimin Zhao

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Characterization And Application Of The Fe(N) And A-Ketoglutarate Dependent Hydroxylase Frbj

机译：Fe（N）和α-酮戊二酸依赖性羟化酶Frbj的表征和应用

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The Fe(n) and a-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials

机译：Fe（n）和α-酮戊二酸依赖性羟化酶FrbJ先前已证明可利用FR-900098合成第二种膦酸酯FR-33289。在这里，我们评估了其羟化其他可能底物的能力，从而生成了潜在的抗疟化合物库。通过一系列的生物测定和体外实验，我们确定了两种新的抗疟药

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《Chemical Communications》 |2011年第36期|p.10025|共1页
作者
Matthew A. DeSieno; Wilfred A. van der Donk; Huimin Zhao;
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Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana,IL 61801, USA Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA;

Departments of Chemistry and Biochemistry, University of Illinois atUrbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801,USAInstitute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA;

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana,IL 61801, USA Departments of Chemistry and Biochemistry, University of Illinois atUrbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801,USA Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USADepartment of Bioengineering, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA;

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入库时间 2022-08-17 13:22:42

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1. Characterization And Application Of The Fe(N) And A-Ketoglutarate Dependent Hydroxylase Frbjf [J] . Matthew A. DeSieno, Wilfred A. van der Donk, Huimin Zhao Chemical Communications . 2011,第37期

机译：Fe（N）和α-酮戊二酸依赖性羟化酶Frbjf的表征和应用
2. Characterization of chimeric pterin-dependent hydroxylases: contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity [J] . Daubner SC, Hillas PJ, Fitzpatrick PF Biochemistry . 1997,第39期

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3. Characteristics and biotechnology applications of aliphatic amino acid hydroxylases belonging to the Fe(II) /α-ketoglutarate-dependent dioxygenase superfamily [J] . Makoto Hibi, Jun Ogawa Applied Microbiology and Biotechnology . 2014,第9期

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5. Characterization of four members of the ferrous ion and alpha-ketoglutarate dependent hydroxylase family from Trypanosoma brucei: Two thymine hydroxylase-like proteins, J-binding protein 1, and an ALKB homolog. [D] . Simmons, Jana M. 2010

机译：来自布氏锥虫的亚铁离子和依赖于α-酮戊二酸的羟化酶家族的四个成员的表征：两个胸腺嘧啶羟化酶样蛋白，J结合蛋白1和ALKB同源物。
6. Characterization and Application of the Fe(II) and α-Ketoglutarate Dependent Hydroxylase FrbJ [O] . Matthew A. DeSieno, Wilfred A. van der Donk, Huimin Zhao -1

机译：表征和铁（II）中的应用和α酮戊二酸依赖性羟化酶FrbJ
7. Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ [O] . Matthew A. DeSieno, Wilfred A. van der Donk, Huimin Zhao 2011

机译：Fe（II）和α-酮戊酸依赖性羟基化酶FRBJ的表征及应用
8. Characterization of the Sites Phosphorylated on Tyrosine Hydroxylase by Ca(2+) and Phospholipid-Dependent Protein Kinase, Calmodulin-Dependent Multiprotein Kinase and Cyclic AMP-Dependent Protein Kinase [R] . Vulliet, P. R., Woodgett, J. R., Ferrari, S., 1985

机译：通过Ca（2+）和磷脂依赖性蛋白激酶，钙调蛋白依赖性多蛋白激酶和环amp依赖性蛋白激酶在酪氨酸羟化酶上磷酸化位点的表征

Characterization And Application Of The Fe(N) And A-Ketoglutarate Dependent Hydroxylase Frbj

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