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Highly enantioselective Friedel-Crafts alkylation reaction catalyzed by rosin-derived tertiary amine-thiourea: synthesis of modified chromanes with anticancer potency

机译:松香衍生的叔胺-硫脲催化的高对映选择性Friedel-Crafts烷基化反应:合成具有抗癌效力的苯并二氢吡喃

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摘要

We present herein for the first time the synthesis and preliminary biological evaluation of various modified chromanes via a rosin-derived tertiary amine-thiourea-catalyzed highly enantioselective Friedel-Crafts alkylation reaction.
机译:我们在此首次通过松香衍生的叔胺-硫脲催化的高对映选择性Friedel-Crafts烷基化反应,对各种改性的苯并二氢吡喃进行合成和初步生物学评估。

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  • 来源
    《Chemical Communications》 |2012年第3期|p.446-448|共3页
  • 作者单位

    State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China,Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

    State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China,Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry,Institute of Biochemistry and Molecular Biology,Lanzhou University, Lanzhou 730000, China;

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  • 入库时间 2022-08-17 13:20:05

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