Second-generation organocatalysts for the highly enantioselective dynamic kinetic resolution of azlactones

摘要

Bifunctional organocatalysts of the thiourea-tert-amine type,carrying two "matched" elements of chirality,effect the alcoholytic dynamic kinetic resolution of a variety of azlactones with up to 95% ee.Enantiomerically pure natural and non-natural a-amino acids find numerous applications in the synthesis of chiral ligands,catalysts,Pharmaceuticals,peptides and many other valuable target molecules.