Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma

Olivier Mir; Stanislas Ropert; Antoine Babinet; Jérôme Alexandre; Frédérique Larousserie; Jean-Philippe Durand; Eric Enkaoua; Philippe Anract; François Goldwasser

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Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma

机译：不用高水合的高碱化预防骨肉瘤患者大剂量甲氨蝶呤的急性肾毒性

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Purpose To evaluate the reliability and renal safety of an original schedule of high-dose methotrexate (HDMTX) administration with hyper-alkalinization, and without hyper-hydration.

机译：目的评估高剂量甲氨蝶呤（HDMTX）高碱化且无高水化的原始时间表的可靠性和肾安全性。

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《Cancer Chemotherapy and Pharmacology》 |2010年第6期|p.1059-1063|共5页
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Olivier Mir; Stanislas Ropert; Antoine Babinet; Jérôme Alexandre; Frédérique Larousserie; Jean-Philippe Durand; Eric Enkaoua; Philippe Anract; François Goldwasser;
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1. Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma. [J] . Mir O, Ropert S, Babinet A, Cancer chemotherapy and pharmacology. . 2010,第6期

机译：无需过度水合作用的高碱化可预防大剂量甲氨蝶呤对骨肉瘤患者的急性肾毒性。
2. 2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity [J] . Francisco Berga, Pablo Luna, Clara Martorell, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2018,第期

机译：在高剂量甲氨蝶呤诱导的肾毒性后，用羧肽酶-G2恢复治疗的患者患者中的2,4-二氨基-N10-甲基哌酸（DAMPA）晶体尿潴留
3. Prospective evaluation of high-dose ifosfamide-related nephrotoxicity in young adult patients with recurrent osteosarcoma previously treated with cisplatin, methotrexate and standard-dose ifosfamide. [J] . Ferrari S, Zolezzi C, Cesari M, Anti-cancer drugs . 1999,第1期

机译：对以前用顺铂，甲氨蝶呤和标准剂量异环磷酰胺治疗的复发性骨肉瘤的年轻成人成年患者大剂量异环磷酰胺相关的肾毒性进行前瞻性评估。
4. Low level and high frequency fragmentation of the QRS changes during acute myocardial ischemia in patients with and without prior myocardial infarction [C] . Gomis Pedro, Caminal Pere Computing in Cardiology Conference . 2014

机译：有和没有先发性心肌梗死的急性心肌缺血期间QRS的低水平和高频断裂
5. Relationship of serum methotrexate concentration in high-dose methotrexate chemotherapy to prognosis and tolerability: A prospective cohort study in chinese adults with osteosarcoma [O] . Feng Lin, Yue Juan, Shui-Er Zheng, 2009

机译：大剂量甲氨蝶呤化疗中血清甲氨蝶呤浓度与预后和耐受性的关系：中国成年人骨肉瘤的前瞻性队列研究
6. Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma [O] . Mir, Olivier, Ropert, Stanislas, Babinet, Antoine, 2010

机译：高碱化而不高水化预防骨肉瘤患者大剂量甲氨蝶呤急性肾毒性

Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma

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