Serum interleukin-8 and insulin like growth factor-1 in Egyptian bladder cancer patients

摘要

Background: Bladder cancer is a major health problem in Egypt as it represents the most common malignancy. Aim: Evaluation of the potential usefulness of serum IL-8 and IGF-1 in Egyptian bladder cancer patients. Methods: Serum levels of IL-8 and IGF-1 were determined in 51 bladder cancer patients and 45 controls using a chemiluminescence enzyme immunometric assay.Results: Serum IL-8 was significantly higher in cancer patients than in controls (P 0.05). There was no relationship between IGF-1 levels and clinicopathological parameters. Conclusions: In Egyptian patients with bladder cancer, serum IL-8 is significantly elevated and its level is related to tumor invasion and associated schistosomal infection. Moreover, serum IGF-1 level does not help as a serum tumor marker in these patients.