PYRIMIDINE DERIVATIVES WHEREIN A NITROGEN HETEROATOM IS ATTACHED AT POSITIONS 2 AND 4 THEREOF, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF SUCH PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS AND AS MEDICAMENTS FOR MODULATING INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR ACTIVITY IN A PATIENT

摘要

The invention provides compounds of formula in which R1, R2, R3 and R4 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.