Stereoselective propranolol metabolism in two drug induced rat hepatic microsomes

propranolol; enantiomers; rat hepatic microsome

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Stereoselective propranolol metabolism in two drug induced rat hepatic microsomes

机译：两种药物诱导的大鼠肝微粒体的立体选择性心得安代谢

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AIM To study the influence of inducers BNF and PB on the stereoselective metablism of propranolol in rat hepatic microsomes. METHODS Phase I metabolism of propranolol Was studied by using the microsomes induced by BNF and PB and the non-induced microsome as The control. The enzymatic kinetic parameters of Propranolol enantiomers were calculated by Regression analysis of Lineweaver-Burk plots. HPLC.

机译：目的研究诱导剂BNF和PB对大鼠肝微粒体中心得安的立体选择性代谢的影响。方法以BNF和PB诱导的微粒体和未诱导的微粒体为对照，研究普萘洛尔I期代谢。普萘洛尔对映体的酶动力学参数是通过Lineweaver-Burk图的回归分析来计算的。 HPLC。

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《World Journal of Gastroenterology》 |2000年第1期|p.74-78|共5页
作者
propranolol; enantiomers; rat hepatic microsome;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
propranolol; enantiomers; rat hepatic microsome;

机译：普萘洛尔对映体大鼠肝微粒体;
入库时间 2022-08-17 23:37:58

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Stereoselective propranolol metabolism in two drug induced rat hepatic microsomes

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