Dual pathway for angiotensin II formation in human internal mammary arteries

摘要

Angiotensin converting enzyme(ACE) is thought to be the main enzyme to convert antiotensin I to the vasoactive angiotensin II. Recently, in the human heart, it was found that the majority of angiotensin II formation was due to another enzyme, identified as human heart chymase. In the human vasculature However, the predominance of either ACE or non-ACE conversion of angiotensin I remains unclear. To study the effects of ACE- and chymase-inhibition on angiotensin II formation in human arteries, Segments of internal mammary arteries were obtained from 37 patients who underwent coronary bypass Surgery.