Oncofetal fibronectin and oral squamous cell carcinoma

摘要

Fibronectin is cell matrix glycoprotein, which exists as a number of isoforms that are often found within the cell matrix that surrounds tumours. Collectively these tumour-associated isomers of fibronectin have been termed oncofetal fibronectin(OFFN). We looked for expression of OFFN within oral squamous cell carci- nomas(SCC)and related its presents to prognosis. The investigation used a monoclonal antibody(MoAb 5C10) to the glycosylated variant of OFFN, and 100 archival specimens of oral SCC. Immunostaining for OFFN was intense in the adjacent stroma of 43 squamous carcinomas, weak in 27 and absent in 30.