DiMoVo: a Voronoi tessellation-based method for discriminating crystallographic and biological protein–protein interactions

摘要

Motivation: Knowledge of the oligomeric state of a protein is often essential for understanding its function and mechanism. Within a protein crystal, each protein monomer is in contact with many others, forming many small interfaces and a few larger ones that are biologically significant if the protein is a homodimer in solution, but not if the protein is monomeric. Telling such ‘crystal dimers’ from real ones remains a difficult task.