Methods of enhancing survival of a coagulation protein by inhibiting interaction with a clearance receptor, of increasing factor viii survival that inhibits coagulation protein depletion receptors, of treating an individual with a blood clotting disease, and of treating a disease characterized by a factor viii deficiency in an individual, and, protein of ... methods of increasing the survival of a coagulation protein by inhibiting interaction with a clearance receptor, of increasing factor viii survival by inhibiting interaction with a clearance receptor, preparing a composition that inhibits coagulation protein clearance receptors, treating an individual with a blood clotting disease, and treating a disease characterized by a factor viii deficiency in an individual, and modified coagulation protein.

摘要

The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.