Suberoyl Bishydroxamic Acid Activates Notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma

Li Ning MD; Renata Jaskula-Sztul PhD; Muthusamy Kunnimalaiyaan PhD; Herbert Chen MD FACS

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Suberoyl Bishydroxamic Acid Activates Notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma

机译：Suberoyl双氧肟酸激活Notch1信号传导并抑制髓样甲状腺癌动物模型中的肿瘤进展。

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Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy that frequently metastasizes and has few treatments. This study was aimed at assessing the antitumor effects of suberoyl bishydroxamic acid (SBHA) in an in vivo model of MTC.

机译：甲状腺髓样癌（MTC）是一种神经内分泌恶性肿瘤，经常转移并且几乎没有治疗方法。这项研究旨在评估MTC体内模型中的亚磺酰双氧肟酸（SBHA）的抗肿瘤作用。

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《Annals of Surgical Oncology》 |2008年第9期|2600-2605|共6页
作者
Li Ning MD; Renata Jaskula-Sztul PhD; Muthusamy Kunnimalaiyaan PhD; Herbert Chen MD FACS;
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作者单位

Endocrine Surgery Research Laboratories Department of Surgery University of Wisconsin School of Medicine and Public Health and the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison WI USA;

Endocrine Surgery Research Laboratories Department of Surgery University of Wisconsin School of Medicine and Public Health and the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison WI USA;

Endocrine Surgery Research Laboratories Department of Surgery University of Wisconsin School of Medicine and Public Health and the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison WI USA;

Endocrine Surgery Research Laboratories Department of Surgery University of Wisconsin School of Medicine and Public Health and the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Madison WI USA;

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正文语种 eng
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关键词
Histone deacetylase inhibitor; Suberoyl bishydroxamic acid (SBHA); Medullary thyroid carcinoma; Local delivery; Notch1; Apoptosis;

机译：组蛋白脱乙酰基酶抑制剂;亚磺酰双氧肟酸（SBHA）;甲状腺髓样癌;局部递送;Notch1;凋亡;
入库时间 2022-08-18 02:06:40

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专利

1. Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. [J] . Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Annals of surgical oncology . 2008,第9期

机译：在甲状腺髓样癌的动物模型中，Suberoyl bishydroxamicamicate激活notch1信号传导并抑制肿瘤进展。
2. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. [J] . Ning L, Greenblatt DY, Kunnimalaiyaan M, The oncologist . 2008,第2期

机译：辛二酰基双-异羟肟酸激活Notch-1信号传导并诱导甲状腺髓样癌细胞的凋亡。
3. Valproic acid suppresses cervical cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin receptor type II [J] . TsaiC., LeslieJ.S., Franko-TobinL.G., Archives of gynecology and obstetrics. . 2013,第2期

机译：丙戊酸可能通过激活Notch1信号传导来抑制子宫颈癌的进展，并通过激活II型生长抑素受体来增强针对受体的癌症化学疗法
4. Label-Free Detection of Tumor Markers in a Colon Carcinoma Tumor Progression Model by Confocal Raman Microspectroscopy [C] . Claudia Scalfi-Happ, Angelika Rueck, Martin Udart, Clinical and biomedical spectroscopy and imaging III . 2013

机译：共聚焦拉曼光谱法在结肠癌肿瘤进展模型中无标记检测肿瘤标志物
5. Constitutively Activated PI3K Signaling Accelerates Tumor Initiation and Progression in Breast and Lung Cancers. [D] . Sheen, Mee Rie. 2014

机译：组成性激活的PI3K信号会加速乳腺癌和肺癌的肿瘤发生和发展。
6. Suberoyl bishydroxamic acid activates Notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma [O] . Li Ning, Renata Jaskula-Sztul, Muthusamy Kunnimalaiyaan, -1

机译：亚甲酰双氢肟酸在甲状腺髓样癌动物模型中激活Notch1信号传导并抑制肿瘤进展
7. Suberoyl bis-hydroxamic acid activates Notch1 signaling and induces apoptosis in anaplastic thyroid carcinoma through p53 [O] . Jiansen Li, Xiangqian Zheng, Ming Gao, 2016

机译：Suberoyl Bis-羟肟酸激活Notch1信号传导，并通过P53诱导血压甲状腺癌中的细胞凋亡

Suberoyl Bishydroxamic Acid Activates Notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma

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