A Predictive model for matrix and analyte effects in electrospray ionization of singly-charged ionic analytes

摘要

In electrospray ionization (ESI), droplets with a surface excess charge are created. The rate of production of surface excess charge is a constant and is equal to the rate of ion production. The ions appearing in the mass spectrum are postulated to be those that formed the surface excess charge at the time of droplet formation(or their collision products). An equilibrium model based on competition among the ions in the solution for the limited number of excess charge sites has been developed.