Metal Complexation Reactions of Quinolone Antibiotics in a Quadrupole Ion Trap

摘要

We have undertaken a systematic study of the nature of quinolone metal complexes formed by electrospray ioniza- tion and laser desorption/ion-molecule reactions to evaluate the analytical utility of metal complexation as an alternative to conventional ionization via protonation. Metal ionization with laser-desorbed copper and nickel ions results in addition products of the form (L+Cu~+) and (L+Ni~+), respectively, where L is the quinolone, whereas addition-elimination products of the form(L+ Co~+ -28) are observed when cobalt is used.