Tazanolast Inhibits Ozone-induced Airway Hyperresponsiveness in Guinea Pigs

摘要

We studied the inhibitory effect of tazanolast, a selective mast-cell-stabilizing drug, on ozone-induced airway hyperresponsiveness in guinea pigs. Airway responsiveness to methacholine peaked at 2 h af- ter ozone exposure(2.0 ppm for 2 h) and the number of neutrophils in bronchoalveolar lavage(BAL) fluid continued to increase until 6 h. tazanolast administered before ozone exposure at doses of 30, 100, or 300 mg/kg inhibited ozone-induced airway hyperresponsiveness in a dose-dependent man- ner.