Effects of spin labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthesis in human lymphoid leukemia Molt 4B cells

摘要

Conclusion: GP4 and GP7 inhibit the proliferation of Molt 4B cells, but The mechanisms are different. Aim: To examine the effect of the spin labeled Derivatives of podophyllotoxin, N-podophyllic Acid-N''-[4-(2,2,6,6-tetramethyl-1-piperidiny- Loxy)]thiosemicarbazide(GP4)and 4-[4''-(2'', 2'',6'',6''-tetramethyl-1''-piperidinyloxy)amino]- 4'-demethylepipodophyllotoxin(GP7)on the cell cycle and macromolecular synthesis of human lumphoid leukemia Molt 4B cells in vitro. Methods: MTT assay, ~3H incorporation, and flow cytometer were used.