Effects of dexamethasone, cyproheptadine, anisodamine, anddinoprostone on TNF_α production in endotoxic shock

摘要

AIM: To study the effects of dexamethasone (Dex), cyproheptadine (Cyp), anisodamine (Ani), and dinoprostone (Din) on lipopolysac- charides (LPS)-induced tumor necrosis factor alpha (TNF_α) gene expression and antishock effects of inhibiting TNF_α production. CONCLUSION: Dex, Cyp, Ani, and Din strongly inhibit LPS-induced TNF_α gene expression, and have a beneficial Antishock effects.