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Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines
Treatment of endotoxic shock by inhibiting production of pro-inflammatory cytokines
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机译:通过抑制促炎细胞因子的产生来治疗内毒素性休克
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摘要
Treatment of endotoxic shock in a mammal comprises administering, in a vehicle, an agent (I) that inhibits production of tumor necrosis factor (TNF) or interleukin-6 (IL-6). ACTIVITY : Antiinflammatory antibacterial immunosuppressive. MECHANISM OF ACTION : Inhibiting production of pro-inflammatory cytokines. Murine peritoneal macrophages were stimulated with lipopolysaccharide (LPS 10 ng/ml) in presence of 0.001 mu M vasoactive intestinal peptide (VIP). The production of IL-6 was about 800 ng/ml in absence of VIP but only about 160 ng/ml in its presence. Production of TNF by the same cells was also suppressed, e.g. the maximum level was reduced from about 1400 pg/ml to about 600 pg/ml.
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机译:哺乳动物内毒素性休克的治疗包括在媒介物中施用抑制肿瘤坏死因子(TNF)或白介素6(IL-6)产生的药物(I)。活动:抗炎抗菌免疫抑制剂。作用机理:抑制促炎细胞因子的产生。在0.001μM血管活性肠肽(VIP)存在下,用脂多糖(LPS 10 ng / ml)刺激小鼠腹膜巨噬细胞。在没有VIP的情况下,IL-6的产量约为800 ng / ml,在有VIP的情况下,其产量仅为160 ng / ml。相同细胞的TNF产生也被抑制,例如。最大水平从约1400 pg / ml降低到约600 pg / ml。
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