Anti-endotoxic shock effects of cyproheptadine in rats

摘要

Conclusion Cyp exerts an anti-endotoxic shock effect by inhibiting TNF_αgene expression, enhancing SOD activity, reducing lipid peroxidation, and preventing[Ca~2+]_i overload. Objective To investigate the antagonistic effect and mechanism of the effect of cyproheptadine(Cyp)on Endotoxic shock in rats. Methods Endotoxic shock was produced in rats by iv injection of lipopolysaccharides(LPS)(5 mg/kg). Tumor necrosis factor(TNF_α)mRNA expression was assessed by Northern blot. Plasma TNF_αcontent was Measured by radioimmunoassay.