Agmatine inhibits carotid sinus baroreflex in anesthetized rats

摘要

(1)Ggn 1, 5, and 10 mmol/L shifted the function curve of carotid si- nus baroreflex to the right and upwards in a concentration- dependent manner with a reduction in peak slope and a reflex decrease in mean arterial pressure, indicating that Agm exerted an inhibitory effect on the carotid barore- Flex.(2)The inhibitory effect of Agm(5 mmol/L)on Baroreflex was eliminated by pretreatment with idazoxan (Ida, 0.1 mmol/L), an α_2-adrenoceptor(α_2-AR)and imidazoline receptor(IR)antagonist, and partially blocked by yohimbine(Yoh, 15μmol/L), a selective α_2-AR antagonist. Agm inhibits carotid baroreflex via IR and α_2-AR.