Pharmacokinetics of lansoprazole in Chinese healthy subjects in relation to CYP2C19 genotypes

摘要

AIM: To study the kinetic characteristics of lansoprazole in healthy Chinese subjects in relation to CYP2C19 genotype status for the individualized dose regimen of lansoprazole. METHODS: Nine homozygous extensive metabolizers (homo EMs) and 9 poor metabolizers (PMs) were recruited for the study from a total of 70 healthy Chinese volunteers, whose CYP2C19 genotype status was determined by the PCR-RFLP techniques: After a single oral dose of 30 mg lansoprazole capsule, plasma concentrations of lansoprazole were determined with HPLC method. RESULTS: In Chinese subjects, the allele frequencies of the CYP2C19m1 and CYP2C19m2 mutation were 0.35 and 0.07, respectively. The concentration-time curves in the two groups were best fitted to a one-compartment model. In the homo EMs and the PMs groups, the main kinetic parameters were as follows: T_(max) (2.44+-0.85) and (2.33+-0.94) h, C_(max)(1.10+-0.34) and (1.73+-0.56) mg/L, Cl/F (16.55+-6.38) and (3.58+-1) L/h, T_(1/2ke)(1.96+-0.51) and (4.21+-0.53) h, AUC were (3.23+-1.08) and (11.05+-3.23) mg·h·L~(-1). A significant difference in AUC, T_(1/2ke), Cl/F, C_(max) values existed between the two groups (P<0.01). CONCLUSION: CYP2C19 genotype is the major factor to influence the interindividual kinetic variability of lansoprazole. Individualized dose regimen of lansoprazole, based on identification of genotype, can be of great benefit for the reasonable use of this drug.