The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes

机译：有机溶质转运蛋白α和β是由人肝细胞缺氧诱导的

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Background & AimsThe organic solute transporters alpha and beta (OSTα-OSTβ) form a heterodimeric transporter located at the basolateral membrane of intestinal epithelial cells and hepatocytes. Liver injury caused by ischaemia-reperfusion, cancer, inflammation or cholestasis can induce a state of hypoxia in hepatocytes. Here, we studied the effect of hypoxia on the expression of OSTα-OSTβ.

机译：背景与目的有机溶质转运蛋白α和β（OSTα-OSTβ）形成位于肠上皮细胞和肝细胞基底外侧膜的异二聚体转运蛋白。由缺血再灌注，癌症，炎症或胆汁淤积引起的肝损伤可引起肝细胞缺氧状态。在这里，我们研究了缺氧对OSTα-OSTβ表达的影响。

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期刊名称 Wiley-Blackwell Online Open
作者
Carlos A Schaffner; Jessica Mwinyi; Zhibo Gai; Wolfgang E Thasler; Jyrki J Eloranta; Gerd A Kullak-Ublick;
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作者单位

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年(卷),期 -1(35),4
年度 -1
页码 1152–1161
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
bile acid transport chronic renal failure gene regulation ligand nephrectomy nuclear receptor organic anion transport rat liver;

机译：胆汁酸运输;慢性肾功能衰竭;基因调控;配体;肾切除术;核受体;有机阴离子运输;大鼠肝脏;

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专利

1. The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes [J] . Schaffner Carlos A., Mwinyi Jessica, Gai Zhibo, Liver international : . 2015,第4期

机译：有机溶质转运蛋白α和β是由人肝细胞缺氧诱导的
2. N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta [J] . Carol J Soroka, Shuhua Xu, Albert Mennone, BMC Cell Biology . 2008,第1期

机译：α亚基的N-糖基化不会影响人类有机溶质转运蛋白alpha / beta的运输或功能活性
3. Characterization of conjugated and unconjugated bile acid transport via human organic solute transporter alpha/beta [J] . Suga Takahiro, Yamaguchi Hiroaki, Ogura Jiro, Biochimica et biophysica acta. Biomembranes . 2019,第5期

机译：通过人有机溶质转运蛋白/β的缀合和未缀合的胆汁酸输送的表征
4. ~(213)Bi-DOTATOC receptor targeted alpha-radionuclide therapy induces remission in neuroendocrine tumors refractory to beta-radiation - a first in human study [C] . Giesel FL, Kratochwil C, Bruchertseifer F, 8th International Conference on Isotopes 2014 . 2014

机译：〜（213）Bi-DOTATOC受体靶向的α-放射性核素疗法可诱导难于β辐射的神经内分泌肿瘤缓解-这是人类研究中的首次
5. Hemicellulose and vitamin-C reduce xenobiotic-induced human T-cell alpha5beta1 integrin-mediated adhesion to fibronectin. [D] . Lee, Sangwoo. 2008

机译：半纤维素和维生素C减少了异种生物诱导的人类T细胞alpha5beta1整合素介导的对纤连蛋白的粘附。
6. N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta [O] . Carol J Soroka, Shuhua Xu, Albert Mennone, 2008

机译：α亚基的N-糖基化不会影响人类有机溶质转运蛋白alpha / beta的运输或功能活性
7. The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes [O] . Schaffner, Carlos A, Mwinyi, Jessica, Gai, Zhibo, 2015

机译：有机溶质转运蛋白α和β是由人肝细胞缺氧诱导的
8. Antiapoptotic Action of Hypoxia-Inducible Factor-1Alpha in Human Endothelial Cells [R] . Yu, E. Z. , Li, Y. , Liu, X. , 2003

机译：缺氧诱导因子-1 1a在人内皮细胞中的抗凋亡作用

The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes

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