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Efficacy and Safety of ABT‐494 a Selective JAK‐1 Inhibitor in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate

机译：选择性JAK-1抑制剂ABT-494在IIb期研究中对类风湿关节炎和对甲氨蝶呤反应不足的患者的疗效和安全性

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ObjectiveTo evaluate the efficacy and safety of ABT‐494, a selective JAK‐1 inhibitor, in patients with moderate‐to‐severe rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX).

机译：目的评估选择性JAK-1抑制剂ABT-494在中度至重度类风湿关节炎（RA）以及对甲氨蝶呤（MTX）反应不足的患者中的疗效和安全性。

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期刊名称 Wiley-Blackwell Online Open
作者
Mark C. Genovese; Josef S. Smolen; Michael E. Weinblatt; Gerd R. Burmester; Sebastian Meerwein; Heidi S. Camp; Li Wang; Ahmed A. Othman; Nasser Khan; Aileen L. Pangan; Steven Jungerwirth;
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年(卷),期 -1(68),12
年度 -1
页码 2857–2866
总页数 10
原文格式 PDF
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1. Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase IIb, randomised, placebo-controlled trial [J] . van Vollenhoven Ronald F., Keystone Edward Clark, Strand Vibeke, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2018,第4期

机译：Tregalizumab在类风湿性关节炎患者中的疗效和安全性和对甲氨蝶呤的不足反应不足：IIB，随机，安慰剂对照试验的结果
2. Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: Outcomes of a randomised Phase IIb study [J] . GenoveseM.C., FleischmannR., FurstD., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2014,第9期

机译：奥洛珠单抗在类风湿性关节炎患者中对TNF抑制剂治疗反应不足的疗效和安全性：IIb期随机研究的结果
3. Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: Outcomes of a randomised Phase IIb study [J] . GenoveseM.C., FleischmannR., FurstD., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2014,第9期

机译：奥洛珠单抗在类风湿性关节炎患者中对TNF抑制剂治疗反应不足的疗效和安全性：IIb期随机研究的结果
4. No adverse physiological responses to infrared whole body hyperthermia in patients with rheumatoid arthritis and ankylosing spondylitis compared to healthy subjects. [C] . F.G.J. OOSTERVELD, E. KOOPMAN, J. OLDE SCHOLTENHUIS, Advances in biomedical research . 2010

机译：与健康受试者相比，类风湿性关节炎和强直性脊柱炎患者对红外全身热疗没有不利的生理反应。
5. Selective cyclooxygenase-2 (COX-2) inhibition and risk of acute myocardial infarction or stroke in a population of rheumatoid arthritis and osteoarthritis patients from an administrative medical claims dataset. [D] . Spalding, William Michael. 2003

机译：来自行政医疗索赔数据集的类风湿关节炎和骨关节炎患者群体中的选择性环氧合酶2（COX-2）抑制和急性心肌梗塞或中风的风险。
6. A Phase IIb Study of ABT‐494 a Selective JAK‐1 Inhibitor in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti–Tumor Necrosis Factor Therapy [O] . Joel M. Kremer, Paul Emery, Heidi S. Camp, -1

机译：类风湿关节炎患者对抗肿瘤坏死因子治疗反应不足的ABT-494（一种选择性的JAK-1抑制剂）的IIb期研究
7. A Phase 2b Study of ABT-494, a Selective JAK1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti–TNF Therapy [O] . Kremer, JM, Emery, P, Camp, HS, 2016

机译：aBT-494（一种选择性JaK1抑制剂）在类风湿性关节炎患者和抗TNF治疗反应不足的相2b研究

Efficacy and Safety of ABT‐494 a Selective JAK‐1 Inhibitor in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate

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