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Modelling Age-Related Changes in the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone in Different CYP2D6 Phenotypes Using a Physiologically Based Pharmacokinetic Approach

机译：使用基于生理的药代动力学方法对不同CYP2D6表型的利培酮和9-羟基利培酮的药代动力学与年龄相关的变化进行建模

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期刊名称 Springer Open Choice
作者
Lisa Alina Kneller; Georg Hempel;
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作者单位

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年(卷),期 -1(37),6
年度 -1
页码 -1
总页数 14
原文格式 PDF
正文语种
中图分类外科学;
关键词
CYP2D6 polymorphism; elderly; PBPK; pharmacokinetics; risperidone;

机译：CYP2D6基因多态性;老年人;PBPK;药代动力学;利培酮;

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专利

1. Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes [J] . Kneller Lisa Alina, Abad-Santos Francisco, Hempel Georg Clinical pharmacokinetics . 2020,第1期

机译：根据细胞色素P450 2D6表型描述了基于生理的药代动力学建模，描述了锂妥酮和9-羟基苯甲酮的药代动力学
2. Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents [J] . SherwinC.M.T., Salda?aS.N., BiesR.R., Therapeutic Drug Monitoring . 2012,第5期

机译：利培酮和9-羟基利培酮的群体药代动力学建模，以估计儿童和青少年的CYP2D6亚群
3. Population pharmacokinetic analysis of risperidone and 9-hydroxyrisperidone with genetic polymorphisms of CYP2D6 and ABCB1 [J] . YooH.-D., ChoH.-Y., LeeS.-N., Journal of pharmacokinetics and pharmacodynamics . 2012,第4期

机译：具有CYP2D6和ABCB1基因多态性的利培酮和9-羟基利培酮的群体药代动力学分析
4. A PSE approach to patient-individualized physiologically-based pharmacokinetic modeling [C] . Roberto Andrea Abbiati, Gaetano Lamberti, Anna Angela Barba European Symposium on Computer Aided Process Engineering . 2015

机译：患者个体化生理学药代动力学建模的PSE方法
5. Applications of Physiologically Based Pharmacokinetic Modelling to Prediction of the Likelihood of Metabolic Drug Interactions in Paediatric Population and Studying Disparities in Pharmacokinetics Between Children and Adults [D] . Salem, Farzaneh. 2014

机译：基于生理的药代动力学模型在小儿人群中代谢药物相互作用的可能性预测和研究儿童与成人之间药代动力学差异的应用
6. Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents [O] . Catherine M. T. Sherwin, Shannon N. Saldaña, Robert R. Bies, -1

机译：利培酮和9-羟基吡酮酮估算儿童及青少年CYP2D6群的人口药代动力学建模
7. Physiologically Based Pharmacokinetic Modeling of Tamoxifen and its Metabolites in Women of Different CYP2D6 Phenotypes Provides New Insight into the Tamoxifen Mass Balance [O] . Dickschen, Kristin, Willmann, Stefan, Thelen, Kirstin, 2012

机译：在不同CYP2D6表型女性中基于他莫昔芬及其代谢物的生理基础药代动力学模型提供了他莫昔芬质量平衡的新见解

Modelling Age-Related Changes in the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone in Different CYP2D6 Phenotypes Using a Physiologically Based Pharmacokinetic Approach

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