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>Glycerol/Glucose Co-Fermentation: One More Proficient Process to Produce Propionic Acid by Propionibacterium acidipropionici
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Glycerol/Glucose Co-Fermentation: One More Proficient Process to Produce Propionic Acid by Propionibacterium acidipropionici
Cosubstrates fermentation is such an effective strategy for increasing subject metabolic products that it could be available and studied in propionic acid production, using glycerol and glucose as carbon resources. The effects of glycerol, glucose, and their mixtures on the propionic acid production by Propionibacterium acidipropionici CGMCC1.2225 (ATCC4965) were studied, with the aim of improving the efficiency of propionic acid production. The propionic acid yield from substrate was improved from 0.475 and 0.303 g g−1 with glycerol and glucose alone, respectively, to 0.572 g g−1 with co-fermentation of a glycerol/glucose mixture of 4/1 (mol/mol). The maximal propionic acid and substrate conversion rate were 21.9 g l−1 and 57.2% (w/w), respectively, both significantly higher than for a sole carbon source. Under optimized conditions of fed-batch fermentation, the maximal propionic acid yield and substrate conversion efficiency were 29.2 g l−1 and 54.4% (w/w), respectively. These results showed that glycerol/glucose co-fermentation could serve as an excellent alternative to conventional propionic acid fermentation.
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机译:共底物发酵是增加主题代谢产物的有效策略,可以利用甘油和葡萄糖作为碳源,在丙酸生产中使用和研究。研究了甘油,葡萄糖及其混合物对产酸丙酸丙酸杆菌CGMCC1.2225(ATCC4965)产生丙酸的影响,目的是提高丙酸的生产效率。通过单独发酵甘油和葡萄糖,底物的丙酸产率分别从0.475和0.303 g g -1 sup>提高到0.572 g g -1 sup>。甘油/葡萄糖混合物为4/1(mol / mol)。丙酸和底物的最大转化率分别为21.9 g l -1 sup>和57.2%(w / w),均明显高于单一碳源。在分批补料发酵的最佳条件下,最大丙酸产量和底物转化效率分别为29.2 g lsup-1 supp和54.4%(w / w)。这些结果表明,甘油/葡萄糖的共同发酵可以作为常规丙酸发酵的优良替代品。
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