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Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase

机译：胸苷酸合酶表达上调的亚叶酸在5-氟尿嘧啶耐药的胃癌细胞中增强5-氟尿嘧啶诱导的细胞毒性

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摘要

BackgroundElucidation of the mechanisms by which gastric cancer cells acquire resistance to 5-fluorouracil (5FU) may provide important clues to the development of effective chemotherapy for 5FU-resistant gastric cancer

机译：背景阐明胃癌细胞获得5-氟尿嘧啶（5FU）耐药性的机制可能为开发对5FU耐药的胃癌的有效化疗提供重要线索

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期刊名称 Springer Open Choice
作者
Ayako Nakamura; Go Nakajima; Ryuji Okuyama; Hidekazu Kuramochi; Yurin Kondoh; Toshinori Kanemura; Teiji Takechi; Masakazu Yamamoto; Kazuhiko Hayashi;
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作者单位

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年(卷),期 -1(17),1
年度 -1
页码 188–195
总页数 8
原文格式 PDF
正文语种
中图分类外科学;
关键词
Gastric cancer 5-Fluorouracil Leucovorin Acquired resistance Thymidylate synthase;

机译：胃癌;5-氟尿嘧啶;叶绿素;获得性耐药;胸苷酸合酶;

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专利

1. Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase [J] . NakamuraA., NakajimaG., OkuyamaR., Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association . 2014,第1期

机译：胸苷酸合酶表达上调的亚叶酸在5-氟尿嘧啶耐药的胃癌细胞中增强5-氟尿嘧啶诱导的细胞毒性
2. 320 Enhancement of 5 fluorouracil (5FU)-mediated cytotoxicity in human gastric cancer (GC) cells by the phosphatidylinositol 3-kinase (PI3K) inhibitor, PI103, via thymidylate synthase (TS) inhibition [J] . B. Bhattacharya, M. Akram, I. Balasubramanian, European Journal of Cancer Supplements . 2010,第7期

机译：320通过胸苷酸合酶（TS）抑制作用的磷脂酰肌醇3-激酶（PI3K）抑制剂PI103增强人胃癌（GC）细胞中5氟尿嘧啶（5FU）介导的细胞毒性
3. Salinomycin enhances cisplatin-induced cytotoxicity in human lung cancer cells via down-regulation of AKT-dependent thymidylate synthase expression [J] . Ko Jen-Chung, Zheng Hao-Yu, Chen Wen-Ching, Biochemical Pharmacology . 2016,第Null期

机译：沙利霉素通过下调AKT依赖性胸苷酸合酶表达来增强顺铂诱导的人肺癌细胞毒性
4. Correlation between Expressions of Estrogen Receptor, Thymidylate Synthase and CAF Regime Sensibility in Breast Carcinoma [C] . Zhang Xiaoli, Zhang Linxi Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：乳腺癌中雌激素受体，胸苷酸合酶表达与CAF病情敏感性的相关性
5. Cigarette Smoking Enhances the Expression of Thromboxane Synthase and Stimulates Lung Cancer Stem Cells, Leading to the Development of Lung Cancer [D] . Liu, Yi. 2015

机译：吸烟可增强血栓烷合酶的表达并刺激肺癌干细胞，从而导致肺癌的发展
6. Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression [O] . Yang Xiao, Usenko Alexander Yurievich, Smorzhevskyi Valentyn Yosypovych 2017

机译：较长的非编码RNA XIST是结直肠癌的预后因素并通过促进胸苷酸合酶表达抑制5-氟尿嘧啶诱导的细胞毒性
7. Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase [O] . Ayako Nakamura, Go Nakajima, Ryuji Okuyama, 2013

机译：胸苷酸合酶表达上调导致亚叶酸在5-氟尿嘧啶耐药的胃癌细胞中增强5-氟尿嘧啶诱导的细胞毒性

Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase

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