首页> 美国卫生研究院文献>Springer Open Choice >Incorporation of omics analyses into artificial gravity research for space exploration countermeasure development
【2h】

Incorporation of omics analyses into artificial gravity research for space exploration countermeasure development

机译:将组学分析纳入人工引力研究中以开发空间探测对策

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。
获取外文期刊封面目录资料

摘要

The next major steps in human spaceflight include flyby, orbital, and landing missions to the Moon, Mars, and near earth asteroids. The first crewed deep space mission is expected to launch in 2022, which affords less than 7 years to address the complex question of whether and how to apply artificial gravity to counter the effects of prolonged weightlessness. Various phenotypic changes are demonstrated during artificial gravity experiments. However, the molecular dynamics (genotype and molecular phenotypes) that underlie these morphological, physiological, and behavioral phenotypes are far more complex than previously understood. Thus, targeted molecular assessment of subjects under various G conditions can be expected to miss important patterns of molecular variance that inform the more general phenotypes typically being measured. Use of omics methods can help detect changes across broad molecular networks, as various G-loading paradigms are applied. This will be useful in detecting off-target, or unanticipated effects of the different gravity paradigms applied to humans or animals. Insights gained from these approaches may eventually be used to inform countermeasure development or refine the deployment of existing countermeasures. This convergence of the omics and artificial gravity research communities may be critical if we are to develop the proper artificial gravity solutions under the severely compressed timelines currently established. Thus, the omics community may offer a unique ability to accelerate discovery, provide new insights, and benefit deep space missions in ways that have not been previously considered.
机译:人类太空飞行的下一个主要步骤包括对月球,火星和近地小行星的飞行,轨道和着陆任务。首次载人深空飞行任务预计于2022年发射,用不到7年的时间来解决复杂的问题,即是否以及如何使用人工重力来抵消长期失重的影响。在人工重力实验中证明了各种表型变化。但是,构成这些形态,生理和行为表型的分子动力学(基因型和分子表型)比以前理解的要复杂得多。因此,可以预期在各种G条件下对对象进行的靶向分子评估会错过重要的分子变异模式,而这些变异会通知通常要测量的更一般的表型。当应用各种G加载范例时,组学方法的使用可以帮助检测整个分子网络的变化。这将有助于检测应用于人或动物的不同重力范式的脱靶或意外影响。从这些方法中获得的见解最终可用于为对策开发提供信息或完善现有对策的部署。如果我们要在当前确定的严格压缩的时间表内开发适当的人工重力解决方案,则组学和人工重力研究界的这种融合可能至关重要。因此,组学界可以提供独特的能力来加速发现,提供新见解并以以前未曾考虑的方式使深空任务受益。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号