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Multicomponent Conjugates of Anticancer Drugs and Monoclonal Antibody with PAMAM Dendrimers to Increase Efficacy of HER-2 Positive Breast Cancer Therapy

机译：PAMAM树状聚合物与抗癌药和单克隆抗体的多组分缀合物可提高HER-2阳性乳腺癌治疗的功效

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PurposeConjugation of nanocarriers with antibodies that bind to specific membrane receptors that are overexpressed in cancer cells enables targeted delivery. In the present study, we developed and synthesised two PAMAM dendrimer-trastuzumab conjugates that carried docetaxel or paclitaxel, specifically targeted to cells which overexpressed HER-2.

机译：目的将纳米载体与结合至在癌细胞中过度表达的特定膜受体的抗体结合，可以靶向递送。在本研究中，我们开发并合成了两种PAMAM树状聚合物-曲妥珠单抗结合物，这些结合物带有多西紫杉醇或紫杉醇，特别是针对过度表达HER-2的细胞。

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期刊名称 Springer Open Choice
作者
Monika Marcinkowska; Maciej Stanczyk; Anna Janaszewska; Ewelina Sobierajska; Arkadiusz Chworos; Barbara Klajnert-Maculewicz;
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作者单位

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年(卷),期 -1(36),11
年度 -1
页码 154
总页数 17
原文格式 PDF
正文语种
中图分类外科学;
关键词
docetaxel HER-2; paclitaxel; PAMAM dendrimer; trastuzumab; tumour targeting;

机译：多西紫杉醇;HER-2;紫杉醇PAMAM树枝状聚合物;曲妥珠单抗肿瘤靶向;

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专利

1. Multicomponent Conjugates of Anticancer Drugs and Monoclonal Antibody with PAMAM Dendrimers to Increase Efficacy of HER-2 Positive Breast Cancer Therapy [J] . Pharmaceutical research . 2019,第11期

机译：抗癌药物和单克隆抗体的多组分缀合物与PAMAM树枝状大分子，增加了患者-2阳性乳腺癌治疗的疗效
2. Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer [J] . Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, Scientific reports. . 2016,第1期

机译：曲妥珠单抗移植的PAMAM树状聚合物可选择性地将抗癌药物递送至HER2阳性乳腺癌
3. Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer [J] . Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, Scientific reports. . 2016,第1期

机译：曲妥珠单抗移植的PAMAM树状聚合物可选择性地将抗癌药物递送至HER2阳性乳腺癌
4. Monocytes Hybridized with PAMAM Dendrimer-Doxorubicin Conjugates for Anticancer Drug Delivery [C] . Christopher A. Holden, W. Andrew Yeudall, Hu Yang Annual meeting of the Society for Biomaterials . 2011

机译：单核细胞与PAMAM树状大分子-阿霉素的缀合物抗癌药物传递。
5. Synthesis of New Generation Taxoid Anticancer Agents and Dendrimer-Based Multifunctional Conjugates for Tumor-Targeting Drug Delivery. [D] . Sun, Yi. 2016

机译：合成新型紫杉类抗癌剂和基于树状聚合物的多功能偶联物，用于靶向肿瘤的药物递送。
6. Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody [O] . Monika Marcinkowska, Maciej Stanczyk, Anna Janaszewska, 2019

机译：PAMAM树状大分子与抗癌药物和单克隆抗体结合的抗肿瘤活性的分子机制
7. Multicomponent Conjugates of Anticancer Drugs and Monoclonal Antibody with PAMAM Dendrimers to Increase Efficacy of HER-2 Positive Breast Cancer Therapy [O] . Monika Marcinkowska, Maciej Stanczyk, Anna Janaszewska, 2019

机译：抗癌药物和单克隆抗体的多组分缀合物与PAMAM树枝状大分子，提高HER-2阳性乳腺癌治疗的疗效
8. Nanoparticle: Monoclonal Antibody Conjugates: A Novel Drug Delivery System in Human Breast Cancer [R] . Sledge, G. W. 2002

机译：纳米粒子：单克隆抗体偶联物：一种新的人乳腺癌药物传递系统

Multicomponent Conjugates of Anticancer Drugs and Monoclonal Antibody with PAMAM Dendrimers to Increase Efficacy of HER-2 Positive Breast Cancer Therapy

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