Monocytes Hybridized with PAMAM Dendrimer-Doxorubicin Conjugates for Anticancer Drug Delivery

摘要

RAW264.7 monocytes showed similar hybridization with PEG-G4.5-DOX as shown in our previous work using PEG-G4.5-AAF. CellTracker labeled monocytes exhibited penetration within tumor spheroids. Cell viability and migration ability will be further examined. In addition, controlled release of DOX from the hybrid vehicle as well as drug penetration and distribution in spheroids will be studied.