Prepubertal testosterone levels are lower in intellectually gifted boys. The aim of this pilot study was to analyze potential genetic factors related to testosterone metabolism in control and gifted boys. Intellectually gifted (IQ>130; n = 95) and control (n = 67) boys were genotyped. Polymorphisms of interests were chosen in genes including androgen and estrogen receptors, 5-alpha reductase, aromatase and sex hormone binding globulin. Significant differences between control and gifted boys in genotype distributions were found for ESR2 (rs928554) and SHBG (rs1799941). A significantly lower number of CAG repeats in the AR gene were found in gifted boys. Our results support the role of genetic factors related to testosterone metabolism in intellectual giftedness. Increased androgen signaling might explain previous results of lower testosterone levels in intellectually gifted boys and add to the understanding of variability in cognitive abilities.
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机译：有天赋的男孩青春期前的睾丸激素水平较低。这项初步研究的目的是分析与正常男孩和有天赋的男孩中睾丸激素代谢有关的潜在遗传因素。对有智力天赋（IQ> 130； n = 95）和对照组（n = 67）的男孩进行基因分型。在包括雄激素和雌激素受体，5-α还原酶，芳香化酶和性激素结合球蛋白的基因中选择了感兴趣的多态性。在ESR2（rs928554）和SHBG（rs1799941）的基因型分布中，对照组和有天赋的男孩之间存在显着差异。在天才男孩中，AR基因中CAG重复的数量明显减少。我们的结果支持与睾丸激素代谢相关的遗传因素在智力天赋中的作用。雄激素信号的增加可能解释了以前有智力天赋的男孩睾丸激素水平降低的结果，并加深了对认知能力变异性的理解。
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