Motor Fatigue Measurement by Distance-Induced Slow Down of Walking Speed in Multiple Sclerosis

摘要

Background and rationaleMotor fatigue and ambulation impairment are prominent clinical features of people with multiple sclerosis (pMS). We hypothesized that a multimodal and comparative assessment of walking speed on short and long distance would allow a better delineation and quantification of gait fatigability in pMS. Our objectives were to compare 4 walking paradigms: the timed 25-foot walk (T25FW), a corrected version of the T25FW with dynamic start (T25FW⁺), the timed 100-meter walk (T100MW) and the timed 500-meter walk (T500MW).