1425. Population Pharmacokinetic Analysis of Ciprofloxacin and Levofloxacin in Critically Ill Trauma Surgical and Burn Patients

摘要

BackgroundAntibiotic pharmacokinetics (PK) differ between critically ill and noncritically ill patients, as do the bacteria causing infection, yet dosing regimens are derived from noncritically ill populations. The purpose of this study was to examine the adequacy of ciprofloxacin and levofloxacin dosing in critically ill trauma, surgery, and burn patients for treating common nosocomial pathogens.