首页> 美国卫生研究院文献>Journal of the Boston Society of Medical Sciences >Establishment and Characterization of an Experimental Model of Coronary Thrombotic Microembolism in Rats
【2h】

Establishment and Characterization of an Experimental Model of Coronary Thrombotic Microembolism in Rats

机译:大鼠冠状动脉血栓微栓塞实验模型的建立与表征

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

To establish a model of coronary thrombotic microembolism in rats, either automicrothrombotic particulates (CM group) or saline control (SHAM group) was injected into temporarily clamped aortas of male Sprague-Dawley rats. After automicrothrombotic particulate injection, serum c-troponin I and von Willebrand factor levels, the no-flow area as evaluated by Thioflavin S, myocardial leukocyte infiltration levels, myocardial expressions of tumor necrosis factor α and interleukin-6, the percentage of arterioles obstructed by thrombosis, and myocardial fibrosis were all significantly increased whereas cardiac function as evaluated by echocardiography and hemodynamic measurements were significantly reduced compared with the sham group. Thus, aortic automicrothrombotic particulate injection could induce coronary microembolism in rats, and this model could be of value in improving the understanding of pathophysiology of coronary microembolism.
机译:为了建立大鼠冠状动脉血栓栓塞的模型,将自身微血栓颗粒(CM组)或生理盐水对照(SHAM组)注射入雄性Sprague-Dawley大鼠的临时钳主动脉中。注射自体微血栓颗粒,血清c-肌钙蛋白I和von Willebrand因子水平,硫黄素S评估的无血流区域,心肌白细胞浸润水平,肿瘤坏死因子α和白介素6的心肌表达,被小动脉阻塞的小动脉百分比与假手术组相比,血栓形成和心肌纤维化均显着增加,而通过超声心动图和血流动力学测量评估的心脏功能显着降低。因此,主动脉自体微血栓形成颗粒注射可诱导大鼠冠状动脉微栓塞,该模型可能对增进对冠状动脉微栓塞的病理生理学的了解具有价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号