H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies

摘要

Viability of adult parasites following exposure to H1-antihistamine drugs. Adult parasites were collected from the hepatic portal and mesenteric veins of mice and placed on plates containing the indicated concentrations of H1-antihistamines. Parasites were monitored for up to 72 h using a microscope and results are expressed as the percent mortality recorded by Kaplan-Meier survival curves. Mean values of viability were derived from a minimum of three experiments (  = 3), and each experiment was performed with five replicates. LC values were determined at 72 h. Control (dashed line): RPMI 1640 + 0.5% DMSO. PZQ, praziquantel at 2 μM