Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images

摘要

class="kwd-title">Keywords: Virchow–Robin spaces, Perivascular spaces, MRI, Small vessel disease class="kwd-title">Abbreviations: WMH, white matter hyperintensities; PVS, perivascular spaces; BG, basal ganglia; CS, centrum semiovale; T1W, T1-weighted MRI sequence; T2W, T2-weighted MRI sequence; PVH, periventricular white matter hyperintensities; DWMH, deep white matter hyperintensities; SVD, small vessel disease class="head no_bottom_margin" id="idm139670669491920title">AbstractPurposePerivascular spaces (PVS) are associated with ageing, cerebral small vessel disease, inflammation and increased blood brain barrier permeability. Most studies to date use visual rating scales to assess PVS, but these are prone to observer variation.