Correlation Between Natural Killer Cell Activity and SystemicInflammatory Markers for Heterogeneous Cancer Patients Treated With WheelBalance Cancer Therapy

摘要

>Background and Objective: Natural killer (NK) cells are known to have an effect on the prevention of tumorigenesis for the initial cancer, as well as the metastatic cancer. For the past several years, the relationship between cancer and inflammation has been actively studied in preclinical and clinical settings, but there are no reports on alterations in and correlation for NK cell activity (NKA) and systemic inflammatory markers. Accordingly, this study aimed to measure correlation between NKA and the levels of other systemic inflammatory markers in patients with gastric, breast, and pancreatic cancer who received Wheel Balance Cancer Therapy (WBCT). >Methods: Forty-two electronic charts of patients with gastric, breast, and pancreatic cancer treated with WBCT from February 1, 2015 to September 30, 2015, were reviewed retrospectively. These charts were statistically analyzed, looking for alterations of and correlation for NKA and the expressions of systemic inflammatory markers. >Results: Patients with a NKA of under 300 pg/mL at admission showed significantly higher erythrocyte sedimentation rate (ESR) and neutrophil-to-lymphocyte ratio (NLR) values and decreasing NLR values due to WBCT than patients with an NKA greater than 300 pg/mL. As a result of thecorrelation analysis between NKA and the levels of the systemic inflammatorymarkers, NKA showed significant negative correlation with NLR, ESR, andfibrinogen values. >Conclusions: Negative correlation was identifiedbetween NKA and NLR, NKA and ESR, and NKA and fibrinogen in patients withheterogeneous cancer patients.