Two Furanosesterterpenoids from the Sponge Luffariella variabilis

摘要

Two new sesterterpenoids, >1 and >2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound >1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound >2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound >2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.