Increased Incidence of Meiotic Anomalies in Oligoasthenozoospermic Males Preselected for Intracytoplasmic Sperm Injection

摘要

>Purpose: Based on data from the literature, to detect thepossible presence of an increased frequency of meiotic anomaliesin oligoasthenozoospermic (OA) patients preselectedfor intracytoplasmic sperm injection.>Methods: Meiotic studies in as many successive patientswith a clinical indication for a diagnostic testicular biopsyas needed to complete at least 100 cases with a severe OA(motile sperm concentration ≤1.5 × 10⁶/ml).>Results: An increased incidence of meiotic anomalies wasfound in 102 patients with a severe OA (17.6%) comparedto the mean for 105 patients with other etiologies in theseries (5.7%) or the mean for patients reviewed in the literature(6.5%).>Conclusions: Patients with a severe OA have a higher incidenceof synaptic anomalies. This may result in themalsegregation of chromosomes at meiosis I, producingabnormal sperm, and could explain the high incidence ofsterility and some cases of abortion (in two thirds of thecouples with abortions the husband had meiotic anomalies)in this group.