Alzheimer’s disease (AD), a persistent neurological dysfunction, has an increasing prevalence with the aging of the world and seriously threatens the health of the elderly. Although there is currently no effective treatment for AD, researchers have not given up, and are committed to exploring the pathogenesis of AD and possible therapeutic drugs. Natural products have attracted considerable attention owing to their unique advantages. One molecule can interact with multiple AD-related targets, thus having the potential to be developed in a multi-target drug. In addition, they are amenable to structural modifications to increase interaction and decrease toxicity. Therefore, natural products and their derivatives that ameliorate pathological changes in AD should be intensively and extensively studied. This review mainly presents research on natural products and their derivatives for the treatment of AD.
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机译：阿尔茨海默病 （AD） 是一种持续的神经功能障碍，随着世界老龄化而日益普遍，严重威胁老年人的健康。虽然目前尚无针对 AD 的有效治疗方法，但研究人员并未放弃，并致力于探索 AD 的发病机制和可能的治疗药物。天然产物因其独特的优势而受到广泛关注。一个分子可以与多个 AD 相关靶点相互作用，因此有可能在多靶点药物中开发。此外，它们还适合进行结构修饰以增加相互作用并降低毒性。因此，应深入和广泛研究改善 AD 病理变化的天然产物及其衍生物。本文主要介绍了天然产物及其衍生物治疗 AD 的研究。
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