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MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2

机译：MicroRNA-365通过负向靶向β-arrestin2来激活ERK / CREB信号通路来减轻吗啡镇痛耐受性

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摘要

BackgroundMorphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tolerance..

机译：背景吗啡在临床上广泛用于一类镇痛药，长期使用吗啡会引起耐受作用。据报道，MicroRNA与吗啡镇痛耐受有关。

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期刊名称 Journal of Biomedical Science
作者
Xian-Ping Wu; Rui-Xuan She; Yan-Ping Yang; Zu-Min Xing; Han-Wen Chen; Yi-Wen Zhang;
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作者单位

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年(卷),期 2018(25),-1
年度 2018
页码 10
总页数 11
原文格式 PDF
正文语种
中图分类医学史;
关键词
microRNA-365 β-arrestin2 Morphine tolerance Extracellular signal-regulated kinase cAMP-response element binding protein;

机译：microRNA-365;β-arrestin2;吗啡耐受;细胞外信号调节激酶;cAMP反应元件结合蛋白;

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专利

1. MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2 [J] . Xian-Ping Wu, Rui-Xuan She, Yan-Ping Yang, Journal of biomedical science. . 2018,第1期

机译：MicroRNA-365通过负向靶向β-arrestin2来激活ERK / CREB信号通路来减轻吗啡镇痛耐受性
2. The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine. [J] . Ozdemir E, Bagcivan I, Durmus N, Canadian Journal of Physiology and Pharmacology . 2011,第2期

机译：一氧化氮-cGMP信号通路在耐受吗啡镇痛作用中起重要作用。
3. Hyperoside Alleviates High Glucose-Induced Proliferation of Mesangial Cells through the Inhibition of the ERK/CREB/miRNA-34a Signaling Pathway [J] . Le Zhang, Qian Dai, Lanlan Hu, International journal of endocrinology . 2020,第2期

机译：通过抑制ERK / CREB / miRNA-34a信号传导途径，使高血清素减轻了高葡萄糖细胞的增殖
4. Involvement of ERK and CREB Signaling Pathways in the Protective Effect of PACAP in Monosodium Glutamate-Induced Retinal Lesion [C] . BOGLARKA RACZ, ANDREA TAMAS, PETER KISS, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：ERK和CREB信号传导途径参与PAPAP在谷氨酸钠诱导的视网膜病变中的保护作用
5. Role of Gut Microbiota in Morphine-induced Analgesic Tolerance [D] . Zhang, Li. 2019

机译：肠道微生物在吗啡诱导的镇痛耐受的作用
6. Hyperoside Alleviates High Glucose-Induced Proliferation of Mesangial Cells through the Inhibition of the ERK/CREB/miRNA-34a Signaling Pathway [O] . Le Zhang, Qian Dai, Lanlan Hu, 2020

机译：通过抑制ERK / CREB / miRNA-34a信号传导途径使高血清素减轻了高葡萄糖细胞的增殖
7. Spinophilin-Targeted Protein Phosphatase-1 Alleviated Inflammatory Pain by Negative Control of MEK/ERK Signaling in Spinal Cord Dorsal Horn of Rats [O] . X.-D. Hu, Y.-N. Liu, Z.-Y. Zhang, 2015

机译：旋癣蛋白靶向蛋白磷酸酶-1通过在大鼠脊髓背角中的MEK / ERK信号传导的阴性控制减轻了炎症疼痛

MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2

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