>Introduction: Fluoxetine is a prototype drug of Selective Serotonin Reuptake Inhibitors. Its active demethylated metabolite has a half life of 7-10 d. Fluoxetine is used to treat depression and is also prescribed in premature ejaculation.>Aim: In the present study dose and duration dependent effects of Fluoxetine on histology of seminal vesicle of the albino rats were observed.>Materials and Methods: The present study was conducted on 36 adult male albino rats. Fluoxetine was administered intraperitoneally for 2 wk, 4 wk and 12 wk with mild (10mg/kg/day), moderate (20mg/kg/day) and severe doses (40mg/kg/day). Histological slides of Seminal vesicle were prepared and stained with Hematoxylin and Eosin stain.>Results: On examination through the light microscope, the proliferation of primary, secondary and tertiary villi, increased crypt/alveoli, increased thickness of lamina propria, decreased epithelial cell height, metaplasia, changes in the amount of luminal eosinophilic secretory material in the form of scanty secretion in lumen of seminal vesicle.>Conclusion: Low doses for long duration and high doses for short duration of Fluoxetine produce histological changes in seminal vesicle of albino rats.
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机译：>简介：氟西汀是选择性5-羟色胺再摄取抑制剂的原型药物。它的活性脱甲基代谢产物的半衰期为7-10 d。 >目标：在本研究中，观察到氟西汀对白化病大鼠精囊组织学的剂量和持续时间依赖性。>材料方法：本研究是对36只成年雄性白化病大鼠进行的。腹腔注射氟西汀2周，4周和12周，轻度（10mg / kg /天），中度（20mg / kg /天）和重度（40mg / kg /天）。 >结果：在光学显微镜下观察，初级，次级和第三级绒毛的增殖，隐窝/肺泡增加，层厚度增厚，制备了精囊组织切片，并用苏木精和曙红染色。固有层，上皮细胞高度减少，化生，精囊腔内分泌稀少形式的腔内嗜酸性粒细胞分泌物质的变化。>结论：长期低剂量，短期高剂量氟西汀的产生在白化病大鼠精囊中产生组织学变化。
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