Drosophila a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2

摘要

SARS-CoV-2 proteome and conservation of human host interacting proteins in fly. A Black bar represents SARS-CoV-2 genome, colored bars below represent the genome-encoded virus proteins. Purple, polyprotein is cleaved through self-protease into non-structural proteins (Nsp) 1–16, shown in pink. The structural virus proteins are depicted in blue: Spike (S), envelope (E), membrane (M) and nucleocapsid (N). The accessory proteins (Orf) are shown in lilac. B Lollipop graph displays the percent of human host proteins with fly orthologs (DIOPT ≥ 2; https://www.flyrnai.org/cgi-bin/DRSC_orthologs.pl) for each SARS-CoV-2 protein virus-host network, as reported by Gordon et al. [1]. Size of lollipop top indicates total number of human interacting proteins in network