Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis

摘要

a Representative wounds from WT or KO mice were shown (scale bar, 1 cm). b Statistical analysis of wound areas were shown as the percentage of each timepoint in comparison to the initial (day 0) wound size. c–h Morphological changes in the wounds of the mice (scale bar, 1 mm). H&E-stained sections described the intact skin (e) and a full-thickness excisional wound of WT mice at day 7 postsurgery (f). Newly formed epithelium (NFE, pink areas) and wound bed (areas under green line) were present in f. Based on this, the percentage of wound closure [length of NFE(green line)/length of NFE+ length of gap between edges of wound epithelium (blue line)] and re-epithelialization (length of NFE) in WT mice (g) and KO mice (h) at D7 were carried out for morphometric analyses (c, d). (Data are the mean ± SD, n = 5 in each group, *P < 0.05, **P < 0.01, vs WT mice).