Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model

摘要

Antioxidant preconditioning enhances the tissue repair function of ADSC transplantation for liver fibrosis in vivo. a Schematic illustration of ADSC therapy in a murine model of liver fibrosis. b Representative images of liver sections stained with H&E and Masson’s trichrome after ADSC transplantation with or without antioxidant pretreatment (scale bar, 100 μm). c The fibrotic surface area of Masson’s trichrome positive stained liver sections (n = 6 per group; *p < 0.05). d Hydroxyproline content of liver tissues after ADSC transplantation with or without antioxidant pretreatment (n = 6 per group; *p < 0.05). ADSCs, adipose tissue-derived mesenchymal stem cells; G-ADSCs, ADSCs pretreated with reduced glutathione; M-ADSCs, ADSCs pretreated with melatonin